Fuko Izumo is a young woman burdened by the "Unluck" anomaly, a supernatural ability that instantly inflicts horrific, fatal accidents upon anyone who touches her skin. Believing she is a danger to humanity and ready to end her life, she is saved on a bridge by an immortal, regenerative man she dubs "Andy," whose "Undead" power makes him immune to her curse and desperate to find a death satisfying enough to end his centuries-long existence.Their fateful meeting attracts the attention of the Union, a clandestine organization of superpowered individuals known as Negators, who neutralize dangerous supernatural anomalies. Led by the strict and powerful Juiz, the Union tasks Andy and Fuko with capturing other Negators and fighting monstrous manifestations called UMA, which are physical embodiments of abstract concepts like weather and language. Andy, eager to experience extreme combat and sensations to spark a worthy death, convinces Fuko to join the Union as a provisional member. Along the way, they form a dysfunctional yet fiercely loyal bond, with Andy fiercely protecting Fuko and helping her overcome her debilitating trauma.As they complete missions, the duo uncovers a terrifying cosmic truth orchestrated by a malevolent god-like entity known as "God," who forces humanity to participate in a cruel, cyclical game governed by Rules and Quests. If the Union fails to complete assigned tasks within a given timeframe, God adds catastrophic new Rules to the world, escalating human suffering. To break this endless loop of misery, the Union must capture the
legendary artifact known as the Apocalypse book and ultimately prepare for a final, apocalyptic war against God Himself.Internal betrayal strikes when Billy, a trusted Union veteran, reveals himself as the leader of Under, a rival extremist faction dedicated to destroying the Union and assassinating God through more violent, radical means. This betrayal forces Fuko and Andy to grow stronger rapidly. Fuko transforms from a timid, suicidal girl into a confident, brilliant tactician who masters her Unluck powers to alter the battlefield. Andy delves into his forgotten past, unlocking dormant memories and mastery over his blood and regeneration.Together with their eccentric Union allies, Andy and Fuko
race against time, fighting across shifting realities and enduring devastating losses. Their ultimate goal transcends mere survival; they are fighting to rewrite the very rules of the universe, ensuring a future where humanity is finally free from divine tyranny and where Andy might finally find the peaceful, permanent death he has craved for ages.