Set against the backdrop of 1985 New York City during the Reagan administration, the intertwined lives of several complex characters collide against the rising tide of the AIDS epidemic. Prioritizing career and reputation, brilliant, closeted lawyer Louis Ironson abandons his partner, Prior Walter, after Prior discovers he has contracted HIV. Devastated by the diagnosis and subsequent abandonment, Prior struggles with his physical decline while being visited by mysterious visions and auditory hallucinations, eventually culminating in a celestial encounter with an angel who proclaims him a prophet. Meanwhile, tormented Mormon lawyer Joe Pitt wrestles deeply with his suppressed homosexuality and his religious faith. His pill-addicted wife, Harper, suffers from severe
psychological fractures, hallucinating an Antarctic wasteland within their marriage. Joe is offered a prestigious appellate court clerkship by the formidable, ruthless conservative attorney Roy Cohn. Cohn, a notorious figure who fiercely denies his own homosexuality and subsequent AIDS diagnosis, orchestrates political influence while facing his impending death and confronting the ghost of Ethel Rosenberg, whom he helped send to the
electric chair. Joe and Louis eventually cross paths, leading to an intense affair that further destabilizes both men. Joe finally comes out to his deeply conservative mother, Hannah, who relocates to New York to rescue her family, and ultimately rejects his wife. Harper leaves Joe, seeking a liberating fresh start. As Prior’s health rapidly deteriorates, he is relentlessly pursued by the Angel, who demands that humanity halt its relentless progress so that God, having abandoned heaven out of fear, might return. Prior adamantly rejects this apocalyptic prophecy, refusing to yield to despair. Supported by his loyal, fiercely loving ex-boyfriend Louis, his nurse friend Belize, and Hannah Pitt, Prior travels to Heaven to confront the angels directly. He successfully demands his life back, returning to earth to live out his remaining time with dignity and defiance. Years later, in 1990, the political landscape and personal lives have shifted irrevocably. The Berlin Wall has fallen, and Roy Cohn has long since died, largely alone and unmourned despite his power. Prior, defying medical odds by surviving much longer than anticipated, gathers with Louis, Belize, and Hannah in Central Park. Reflecting on the immense losses and generational trauma of the AIDS crisis, Prior delivers a poignant manifesto on endurance, resilience, and humanity. He asserts that the grand machinery of the world keeps turning and that living, loving, and hoping remain radical acts of survival in a broken universe.