Set ten thousand years before the rise of Paul Atreides, *Dune: Prophecy* explores the origins of the Bene Gesserit sisterhood through the ambitious efforts of sisters Tula and Valya Harkonnen. Traumatized by the downfall of their Great House during the brutal Butlerian Jihad—a cataclysmic war against thinking machines—the siblings dedicate their lives to ensuring humanity never again falls victim to artificial intelligence or unchecked chaos. To achieve this, they establish a shadowy, disciplined order of women who manipulate the Imperium from
behind the scenes, mastering psychological conditioning, combat, and
political intrigue.Valya, serving as the formidable Mother Superior, ruthlessly guides the sisterhood's long-term breeding program, aiming to engineer a messianic bloodline that can control the galaxy. Meanwhile, Tula manages the inner workings of the order, dealing with the psychological tolls and biological experiments necessary to maintain their burgeoning power. However, their secretive foundation faces immediate threats from the highest echelons of power. Emperor Javicco Corrino struggles to maintain stability across a fractured Imperium, caught between the demands of the Great Houses, the lingering anti-technology dogmas, and the dangerous influence of the sisterhood operating within his own court.The delicate balance of power is violently disrupted by the arrival of Desmond Hart, a charismatic and enigmatic soldier who survives a mysterious trauma in the desert. Possessing strange, seemingly supernatural abilities that defy the laws of the post-Jihad universe, Hart quickly becomes a disruptive force. He harbors a deep, fanatical hatred for the Sisterhood and their secretive manipulations, viewing them as a threat to humanity's future. Hart begins systematically undermining Valya’s influence by winning the favor of the Emperor and exposing long-buried secrets.As Hart gains momentum, deep-seated paranoia takes root. Valya realizes that her grand vision for the sisterhood is in jeopardy, forcing her to resort to extreme measures of assassination, espionage, and manipulation. Tula grapples with moral dilemmas as the methods required to protect the order become increasingly ruthless. Secrets from the Harkonnen past threaten to resurface, and rival factions within the Imperium plot to dismantle the sisterhood entirely. Ultimately, *Dune: Prophecy* charts a high-stakes chess match of survival, sacrifice, and genetic destiny, proving that the foundation of the Imperium was built not on nobility, but on the calculated shadows cast by the Sisterhood.