Set as a psychological, neo-noir prequel to the iconic franchise, the series follows the enigmatic and alluring Fujiko Mine as a dangerous femme fatale navigating a surreal, hyper-sexualized
criminal underworld. Fujiko operates primarily as a thief, assassin, and seductress, driven by a deeply buried, fragmented trauma from her past involving a mysterious cult and a powerful
chemical weapon known as the "Fixer."The narrative kicks off when Fujiko targets Count Luis, a wealthy aristocrat harboring the secret of the Fixer—a substance that induces profound, pliable hallucinations. During this heist, Fujiko crosses paths with Arsène Lupin III, a brilliant, eccentric master thief who instantly becomes infatuated with her. Despite Lupin's romantic and protective pursuits, Fujiko’s fierce independence and shifting allegiances keep her perpetually out of reach. Meanwhile, Lupin is relentlessly pursued by Inspector Koichi Zenigata of Interpol, while Fujiko herself is hunted by Zenigata's rival, the ruthless Assassin Aizen, and manipulated by her handler, the Owl.As the series progresses, the plots grow increasingly bizarre and grotesque, exploring themes of identity, memory, and sexuality. Fujiko takes on various dangerous jobs, often betraying employers and allies alike. She forms a complex, uneasy dynamic with Zenigata’s tacitex partner, Daisuke Jigen, who aids her in surviving several near-death encounters, and later encounters Goemon Ishikawa XIII, a stoic samurai who initially seeks her execution before realizing the deeper conspiracies at play.The climax forces Fujiko to confront her suppressed memories at the heart of the Owl’s cult. It is revealed that the cult's leader used the Fixer to manipulate Fujiko's mind, making her an unwitting vessel for their experiments. With the reluctant assistance of Lupin, Jigen, and Goemon—who have formed a loose camaraderie despite their individual motives—Fujiko infiltrates the cult's stronghold. In a surreal, hallucinatory final showdown, Fujiko confronts the ghosts of her childhood and defeats her abusers. Though the ordeal exposes the terrifying depths of her past, Fujiko refuses to be defined or rescued by Lupin. True to her nature, she vanishes into the night once again, leaving Lupin captivated and heartbroken, cementing her status as the ultimate, untouchable femme fatale.