The film is an anthology of six distinct, darkly comedic tales set in the
American frontier. The opening segment introduces Buster Scruggs, a
singing cowboy who appears charming and whimsical but is actually a ruthless, lightning-fast gunslinger. After inadvertently causing trouble in a rough saloon, he enters a brutal shootout, effortlessly defeating every opponent through trickery and uncanny marksmanship. His hubris peaks when he faces a younger challenger known as the Kid, who ultimately shoots Buster dead. Buster’s soul literally floats up to heaven with angel wings, strumming a ukulele. The second story follows a taciturn bank robber who is captured during a botched heist and sentenced to hang. Before the gallows can spring, Comanche raiders attack, killing the lawmen. He is rescued by a passing drover, only to be recaptured by a different patrol and finally hanged. The third tale, "Meal Ticket," focuses on an aging impresario who tours the West with an armless and legless orator named Harrison. Harrison recites classic literature to dwindling audiences. As ticket sales plummet, the impresario finds a literal chicken that can calculate math problems. Seeking greater profits, he coldly pushes Harrison off a high bridge into a freezing river to replace him with the performing fowl. The fourth segment, "All Gold Canyon," features an enthusiastic prospector who carves a pristine valley into a mining site, driven by his obsessive quest for a massive gold vein he calls "Mr. Pocket." After relentless digging, he unearths a giant nugget, only to be ambushed and shot by a hidden claim jumper. The prospector feigns death, turns the tables, and kills the assailant, nursing his wounds before packing up his immense wealth and departing the scarred land. The fifth story, "The Gal Who Got Rattled," centers on Alice Longabarrack, a timid young woman traveling across the plains in a wagon train after her brother’s sudden death. Unable to afford the fee for her transport, she agrees to marry a wagon scout named Billy. When Alice wanders off and gets lost, a tracker rescues her from Native Americans, but mistakenly believes she is about to be captured and shoots her. Believing she is doomed, Alice tragically commits suicide. The final segment, "The Mortal Remains," takes place inside a stagecoach at dusk. Five eccentric passengers—a trapper, a French debunker, an Irish bounty hunter, an English bounty hunter, and a nervous lady—pass the time by arguing about human nature, love, and morality. The two bounty hunters reveal they are transporting a corpse. As they sing a haunting folk song, the coach arrives at a sinister, glowing hotel. The passengers realize they have died and are hesitant to enter, but the bounty hunters usher them inside, walking purposefully toward the great unknown.