Rose Lorkowski, a former high school cheerleader turned dispirited Albuquerque maid, struggles to support her quirky son Oscar and her perpetually flaky, activist sister Norah. Burdened by debt and a lack of professional prospects, Rose’s dead-end life hits a breaking point when she embarks on an affair with her married high school sweetheart, Mac, now a successful real estate agent. Driven by a desperate desire to afford private schooling for Oscar, Rose eagerly accepts Mac’s suggestion to enter the lucrative, albeit grim, world of bioremediation—specializing in crime scene and trauma cleanup.Teaming up with the reluctant Norah, the sisters launch "Sunshine Cleaning," a fledgling enterprise. Initially, Norah is repulsed by the visceral reality of cleaning up blood,
decomposition, and bodily fluids, while Rose grapples with the emotional weight of entering strangers' most tragic domestic spaces. Despite the grim nature of the work, the business slowly gains momentum, aided by Winston, a warm-hearted one-armed prosthetic salesman who befriends Rose and supplies her with specialized cleaning equipment.The dangerous and emotionally heavy job forces both sisters to confront deep-seated personal trauma, particularly the unresolved grief surrounding their mother’s suicide years prior. Norah, deeply affected by the crime scenes, uses the job as a catalyst to search for a deeper connection to her past. She tracks down her mother’s
estranged friend, which ultimately brings her a sense of closure. Meanwhile, Rose’s relationship with Mac shatters when she realizes he has no intention of leaving his wife, forcing her to finally sever ties with her past and reclaim her independence.As the business grows, disaster strikes when Norah, grappling with erratic behavior and exhaustion, accidentally burns down Rose’s house while attempting to clean up a hoarding site. This devastating fire costs them their equipment, strains their sibling bond, and lands Rose in jail. However, the crisis serves as a crucible, melting away their remaining bitterness and uniting them. Mac posts Rose’s bail, and though their romantic affair is permanently over, he offers genuine support.Ultimately, Sunshine Cleaning closes its doors, but the sisters emerge transformed. Rose, finally shedding her need for validation from men and her high school glory days, finds a renewed sense of self-worth and pursues a legitimate career path. Norah finds emotional stability and a clearer direction for her life. The film concludes with the sisters sharing a quiet, hopeful moment, realizing that while life is inevitably messy, they possess the resilience to clean up their own lives and start anew.