Master thief Lupin III is relaxing in his supposed grave, having recently been executed by hanging in Transylvania. However, his loyal gunman companion Jigen and samurai ally Goemon refuse to believe their friend is truly dead. Soon, Lupin reveals himself alive and well, though their celebration is cut short when a mysterious syndicate and Inspector Zenigata capture Lupin’s alluring yet treacherous partner, Fujiko Mine. Fujiko is brought before her eccentric employer, an immortal mastermind named Mamo. Mamo desires the legendary Philosopher’s Stone—a
mythical artifact said to grant
eternal youth—and has manipulated Fujiko into stealing it for him. Lupin, eager for both the treasure and Fujiko, sets out to intercept them.As the gang pursues Mamo, they discover the villain operates from a high-tech pyramid base and possesses god-like technological power. Mamo uses his vast resources to brainwash Fujiko and manipulate global superpowers by threatening nuclear war unless they submit to his rule. Lupin, Jigen, and Goemon infiltrate Mamo’s secret desert headquarters, navigating bizarre deathtraps and clones. Throughout the harrowing journey, Lupin’s casual demeanor clashes sharply with the existential dread of their adversary. Mamo reveals a staggering revelation: he is the original human creator of mankind, having preserved his consciousness and cloned his body for millennia, and he has chosen Fujiko to be his eternal mate in a twisted bid to continue human history under his singular, narcissistic vision.Tensions peak when Lupin manages to rescue Fujiko, only to face Mamo's relentless pursuit across ancient Egyptian ruins and outer space. Mamo captures Fujiko once again, intending to launch himself and her into the cosmos to start a new civilization. Lupin and his crew board Mamo’s rocket just before launch. Inside the spacecraft, Lupin confronts Mamo, destroying his life-support systems and machinery. It is ultimately revealed that Mamo is not a god, but rather an unstable, aging computer mind connected to a vast network of cloned bodies. As the rocket’s systems fail, Mamo’s empire collapses into chaos. Lupin, Jigen, and Goemon manage a daring escape back to Earth, leaving Mamo trapped in orbit to burn up upon re-entry. In the aftermath, Fujiko attempts to double-cross the gang once more for a hidden stash of wealth, but Lupin outsmarts her with trademark charm. The crew reunites on the open road, driving off into the sunset for their next chaotic adventure, leaving Zenigata and the authorities far behind once again.