In 1999 Philadelphia, free-spirited and impulsive Jamie breaks up with her girlfriend Sukie, while her timid, repressed friend Marian desperately needs a change of pace to overcome her paralyzing inhibitions. Seeking a fresh start and a liberating road trip to Tallahassee for a lesbian convention, Marian reluctantly agrees to use a car rental service, unknowingly receiving a "drive-away" vehicle packed with dangerous cargo.Simultaneously, a pair of bumbling local criminals, Santos and Flint, are frantically searching for the exact same car. Hidden inside the vehicle is a mysterious briefcase containing the freshly severed head of a prominent local politician, alongside a substantial cash payoff. Unaware of the lethal stakes or the frantic gangsters trailing their every move, Jamie and Marian hit the open road, completely focused on adventure, relaxation, and romantic escapades.Along the way, the mismatched duo encounters a series of eccentric characters, forcing Marian to break out of her shell while testing the limits of their long-standing friendship. Jamie enthusiastically pursues casual hookups at every stop, occasionally dragging Marian into bizarre situations. Meanwhile, Santos and Flint relentlessly pursue the girls across state lines, though their sheer incompetence continually leads to missed connections and comedic disasters. Eventually, the mob boss who hired the crooks grows impatient with the botched recovery efforts and sends a cold-blooded enforcer named Arlyn to handle the retrieval personally, raising the peril significantly.The journey reaches a chaotic climax in Florida when the mobsters finally intercept the women at a local motel. In the ensuing confrontation, a series of double-crosses and misunderstandings unravels. It is revealed that the briefcase contents are tied up in a convoluted political blackmail scheme. Utilizing unexpected
resourcefulness, Jamie and Marian manage to outsmart the criminals, accidentally destroying the briefcase and its grim contents in the process.With the immediate threat neutralized and the mob organization thrown into disarray, the criminals are left empty-handed. Jamie and Marian finally arrive in Tallahassee, profoundly transformed by their harrowing yet exhilarating cross-country ordeal. Their bond is ultimately strengthened by the shared chaos, leading to a newfound sense of personal freedom, confidence, and empowerment. Having successfully navigated the bizarre
criminal underworld and escaped with their lives, the two friends embrace their futures with renewed vigor, ready to tackle whatever comes next on their own terms.