Set in 1967 suburban Minnesota, Larry Gopnik is a mild-mannered
physics professor whose life rapidly unravels. Larry is up for a permanent tenure position at the university, but his quiet existence is suddenly derailed on multiple fronts. His wife, Judith, abruptly demands a divorce so she can marry Sy Ableman, a pompous family friend. To add insult to injury, Judith evicts Larry from his own home, forcing him and his chronically unemployed brother Arthur to move into a cheap local motel.Larry’s professional life proves equally chaotic. Anonymous, slanderous letters are sent to the tenure committee, jeopardizing his promotion. Simultaneously, a foreign student named Clive attempts to bribe Larry for a passing grade to maintain his scholarship, leaving a heavy envelope of cash on Larry's desk. When Larry attempts to return the money, misunderstandings compound, threatening his academic integrity further. Seeking guidance and spiritual clarity, Larry turns to the local rabbis for help. However, the junior rabbi offers platitudes about looking at the parking lot, while the senior rabbi, the revered Marshak, is perpetually unavailable, leaving Larry isolated with his mounting existential dread.Meanwhile, Larry’s family responsibilities weigh heavily upon him. He must pay for his son Danny’s upcoming Bar Mitzvah, despite having his bank accounts frozen by Judith. Danny is preoccupied with smoking marijuana during Hebrew school and trying to recover his stolen transistor radio, frequently tuning out the pressures around him. Larry's daughter, Sarah, is obsessed with stealing money from his wallet to finance a future nose job.As the narrative progresses, Larry faces a cascade of increasingly bizarre misfortunes, including the sudden,
accidental death of Sy Ableman in a car crash. Believing this tragedy might alleviate his divorce expenses, Larry is horrified to learn he is expected to pay for Sy’s lavish funeral instead. Desperate and overwhelmed by his inability to understand the universe, Larry eventually caves under the financial pressure and decides to change Clive’s failing grade to a passing one, hoping to resolve at least one crisis and secure his bribe money.Just as Larry receives the long-awaited news that he has officially been granted tenure—meaning his financial troubles might finally be over—a series of ominous developments hit. Arthur is arrested for a minor public indecency charge, requiring an expensive lawyer, and Larry’s doctor calls with urgent, alarming news about his recent chest X-rays, suggesting a serious medical condition. Simultaneously, a massive, destructive tornado bears down directly on the children's Hebrew school where Danny is currently participating in outdoor activities, leaving the film on a chilling, ambiguous note of impending catastrophe.